Anti Retroviral Therapy: Different classes of antiretroviral drugs act at different stages of the HIV life cycle. Combination of several (typically three or four) antiretroviral drugs is known as Highly Active Anti-Retroviral Therapy (HAART).
Different classes of Drugs Fact Sheets (information in English and Spanish from AIDS Infonet)
ANTIRETROVIRAL AGENTS
There are currently 6 major classes of antiretroviral drugs :
Nucleoside Analog Reverse Transcriptase Inhibitors (NRTIs, Nukes)
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs or Non-Nukes)
Protease Inhibitors (PI)
Entry and Fusion Inhibitors
Integrase Inhibitors
Maturation Inhibitors
Multi-Class Combination Drug
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Atripla (efavirenz + tenofovir + emtricitabine) |
Nucleoside Analog Reverse Transcriptase Inhibitors (NRTIs, Nukes)
Combivir (zidovudine + lamivudine, AZT + 3TC)
Emtriva (emtricitabine, FTC)
Epivir (lamivudine, 3TC)
Epzicom (Kivexa, abacavir + lamivudine, ABC + 3TC)
Retrovir (zidovudine, AZT, ZDV)
Trizivir (abacavir + zidovudine + lamivudine, ABC + AZT + 3TC)
Truvada (tenofovir DF + emtricitabine, TDF + FTC)
Videx & Videx EC (didanosine, ddI)
Viread (tenofovir disoproxil fumarate, TDF)
Zerit (stavudine, d4T)
Ziagen (abacavir, ABC)
| Racivir (RCV) |
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Amdoxovir (AMDX, DAPD) |
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Apricitabine (SPD754, AVX754) |
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Elvucitabine (ACH-126,443, Beta-L-Fd4C) |
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs or Non-Nukes)
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Rescriptor (delavirdine, DLV) |
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Sustiva (Stocrin, efavirenz, EFV) |
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Viramune (nevirapine, NVP) |
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Etravirine (TMC-125) |
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Rilpivirine (TMC-278) |
Protease Inhibitors
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Agenerase (amprenavir, APV) |
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Aptivus (tipranavir, TPV) |
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Crixivan (indinavir, IDV) |
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Invirase (saquinavir, SQV) |
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Kaletra (Aluvia, lopinavir/ritonavir, LPV) |
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Lexiva (Telzir, fosamprenavir, FPV) |
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Norvir (ritonavir, RTV) |
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Prezista (darunavir, DRV) |
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Reyataz (atazanavir, ATZ) |
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Viracept (nelfinavir, NFV) |
Entry and Fusion Inhibitors
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Fuzeon (enfuvirtide, ENF, T-20) |
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Selzentry (Celsentri, maraviroc, UK-427,857) |
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Vicriviroc (SCH-417690, SCH-D) |
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TNX-355 |
Integrase Inhibitors
| Isentress (raltegravir, MK-0518) |
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Elvitegravir (GS-9137) |
Maturation Inhibitors
Bevirimat (PA-457)
Cellular Inhibitors
Droxia or Hydrea (hydroxyurea, HU)